Tag: preclinical
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Engineered Tissue-Polymer Replacement Spinal Discs Developed
Vertebrae discs made with engineered tissue from stem cells and biocompatible polymer hydrogels were shown in test with lab animals to have comparable properties to natural spinal discs.
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RNA Therapy Helps Reduce Preeclampsia Symptoms
Experimental treatments with engineered RNA are shown in lab animals to reduce symptoms of preeclampsia, a disorder causing high blood pressure in pregnant women.
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Modified Cancer Drug Hastens Bone Fracture Healing
A current drug for leukemia, with a simple protein chemically added, is shown in tests with lab mice to accelerate the healing of broken bones.
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NIH Award Supports Esophagus Tissue Implants from Stem Cells
A company developing engineered tissue implants from stem cells received a grant from National Institutes of Health to develop an implant to correct a congenital defect in a newborn infant’s esophagus.
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NIH Stops Stem Cell Heart Failure Trial Over Retracted Data
National Heart, Lung, and Blood Institute, or NHLBI, part of the National Institutes of Health is suspending a clinical trial of stem cells to regenerate new heart muscle.
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Harvard Spin-Off, AbbVie Partner on Fibrosis Treatments
Drug maker AbbVie and biotechnology company Morphic Therapeutic are collaborating on new treatments for fibrosis based on Morphic’s technology blocking proteins that promote fibrosis.
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Antibody Designed to Stop Inflammation Protein in Brain
A synthetic antibody is shown in tests with lab mice to block the blood protein fibrin from causing inflammation and related damage to brain cells found in neurodegenerative diseases.
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Electro-Pharmaceutical Device Tested to Heal Nerve Injuries
An implanted electronic device is shown in tests with lab rats to help heal peripheral nerve injuries, after which the device degrades and is absorbed into the body.
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Prenatal Genome Edits Prevent Inherited Liver Disorder
Research with lab mice shows prenatal genome editing with techniques including Crispr can correct an inherited defect associated with a fatal congenital liver disorder.
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Human Antibodies Devised for Snakebite Treatment
An academic-industry team in Europe and Central America assembled a group of human antibodies that protects lab mice against venomous toxins from a dangerous African snake.