Tag: clinical trials
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566 New Drugs in Pipeline for Orphan Diseases
9 May 2016. A report by an industry group says 566 drugs designed to treat rare diseases are now in clinical testing by pharmaceutical companies. The report, prepared by Pharmaceutical Research and Manufacturers of America, or PhRMA, and the ALS Association, credits many of these new drugs to incentives in legislation encouraging research and development…
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Trial Underway Testing Antibody for Celiac Disease
5 May 2016. A clinical trial testing an engineered antibody therapy for celiac disease in people that do not respond to a gluten-free diet began treating its first patients. The trial is conducted by Celimmune LLC, a biopharmaceutical company in in Lebanon, New Jersey, but patients are recruited in Finland, where the rate of celiac…
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Drug Pricing Reform Even Big Pharma Might Like
2 May 2016. At a press event in Washington, D.C. last week, Representative Lloyd Doggett of Texas, a champion of lower prescription drug prices, took aim at drug companies and their business practices. “An unaffordable drug is 100 percent ineffective,” Doggett told an audience at Center for American Progress on 26 April. He noted that…
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Engineered T-Cells Get High Leukemia Remission in Trial
28 April 2016. A clinical trial shows engineered immune-system cells transplanted in patients with one form of leukemia achieves a 93 percent remission rate. Results of the trial, at the Fred Hutchinson Cancer Research Center in Seattle, were reported in the 25 April issue of The Journal of Clinical Investigation. Fred Hutchinson Center researchers were…
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Trials to Test New Treatments for Inherited Alzheimer’s
25 April 2016. Clinical trials are planned to assess experimental treatments and new diagnostics for inherited forms of Alzheimer’s disease. The new studies, which extend earlier trials of drugs to treat inherited Alzheimer’s disease, are funded by a $4.3 million grant from Alzheimer’s Association in Chicago. Like the earlier trials, the new round of studies…
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NIH Closes Two Clinical Facilities for Sterility Issues
20 April 2016. National Institutes of Health closed two of its clinical facilities found not in compliance with safety and quality standards that could put patients at risk. Facilities at NIH closed for not meeting Current Good Manufacturing Practice standards are a cell therapy production lab at National Cancer Institute and a production center for…
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Therapy Shown to Boost Immune System Against Cancer
18 April 2016. An experimental treatment was shown in lab mice to enhance immune system cells that can help immunotherapy drugs to reduce solid tumor growth. Researchers from Memorial Sloan Kettering Cancer Center in New York and Infinity Pharmaceuticals in Cambridge, Massachusetts presented their findings yesterday (17 April) at the annual meeting of American Association…
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Many Clinical Trial Protocol Changes Avoidable, Costly
12 April 2016. When clinical trials make changes in plans, known as protocol amendments, after they’re underway, the impact in time and costs are substantial, with many changes considered avoidable. These are conclusions of a review of clinical trial protocol amendments carried out by Center for the Study of Drug Development at Tufts University in…
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NIH Funds Biosensors to Monitor Oxygen in Tissue
11 April 2016. Profusa Inc., a company designing sensors that measure tissue oxygen levels in individuals with peripheral artery disease, received an NIH grant to advance its technology. The $225,000 Small Business Innovation Research grant for 2016 is divided between two agencies of National Institutes of Health: National Center for Advancing Translational Sciences and National…
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Cancer Centers, Analytics, Pharma Plan Precision Medicine
7 April 2016. A cancer care center network, with pharmaceutical and informatics companies, plan to apply precision medicine techniques to increase the pool of patients for clinical trials of new cancer therapies. The coalition includes cancer centers in the Orien network — short for Oncology Research Information Exchange Network — with bioinformatics company M2Gen, and…