{"id":2099,"date":"2010-11-17T18:13:11","date_gmt":"2010-11-17T23:13:11","guid":{"rendered":"http:\/\/sciencebusiness.technewslit.com\/?p=2099"},"modified":"2010-11-17T18:13:11","modified_gmt":"2010-11-17T23:13:11","slug":"trial-shows-catheter-based-therapy-reduces-hypertension","status":"publish","type":"post","link":"https:\/\/technewslit.com\/sciencebusiness\/?p=2099","title":{"rendered":"Trial Shows Catheter-Based Therapy Reduces Hypertension"},"content":{"rendered":"<figure id=\"attachment_2101\" aria-describedby=\"caption-attachment-2101\" style=\"width: 300px\" class=\"wp-caption alignright\"><a href=\"http:\/\/technewslit.com\/sciencebusiness\/wp-content\/uploads\/2010\/11\/RDN_Catheter_Illus_ArdianInc.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-2101\" title=\"RDN_Catheter_Illus_ArdianInc\" src=\"http:\/\/technewslit.com\/sciencebusiness\/wp-content\/uploads\/2010\/11\/RDN_Catheter_Illus_ArdianInc.jpg\" alt=\"RDN Catheter illustratiion (Ardian Inc.)\" width=\"300\" height=\"199\" srcset=\"https:\/\/technewslit.com\/sciencebusiness\/wp-content\/uploads\/2010\/11\/RDN_Catheter_Illus_ArdianInc.jpg 300w, https:\/\/technewslit.com\/sciencebusiness\/wp-content\/uploads\/2010\/11\/RDN_Catheter_Illus_ArdianInc-150x99.jpg 150w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><figcaption id=\"caption-attachment-2101\" class=\"wp-caption-text\">Illustration of a renal denervation catheter (Ardian Inc.)<\/figcaption><\/figure>\n<p>Data from a <a href=\"http:\/\/www.ardian.com\/pdfs\/Symplicity%20HTN-2%20release%20final.pdf\">clinical trial<\/a> of a hypertension therapy using a catheter indicates the device significantly reduced the treated patients&#8217; blood pressure compared to a control group. Results of the HTN-2 trial of the Symplicity system made by <a href=\"http:\/\/www.ardian.com\/index.shtml\">Ardian Inc.<\/a> of Mountain View, California were reported at the American Heart Association <a href=\"http:\/\/www.nxtbook.com\/tristar\/aha\/final_program2010\/index.php#\/68\">Scientific Sessions 2010 <\/a>and published in the journal <a href=\"http:\/\/www.thelancet.com\/journals\/lancet\/article\/PIIS0140-6736%2810%2962039-9\/abstract\">The Lancet<\/a> (paid subscription required).<\/p>\n<p>The study showed that, after six months, patients treated with Ardian&#8217;s device experienced an average drop in blood pressure of 32\/12 mmHg (systolic\/diastolic millimeters of mercury) compared to an increase in blood pressure of 1\/0 mmHg in the control group of patients treated with medications alone.<\/p>\n<p>The HTN-2 trial was an international, multi-center, prospective, randomized, and controlled study of the safety and effectiveness of renal denervation (RDN) in patients with uncontrolled hypertension. RDN involves inserting a small catheter in the into the femoral artery in the upper thigh and threaded into the renal artery. Once in place in the renal artery, the device delivers low-power radio frequency energy to deactivate the surrounding renal sympathetic nerves. This, in turn, reduces hyper-activation of the sympathetic nervous system, which is often the cause of chronic hypertension. The one-time procedure aims to permanently reduce blood pressure.<\/p>\n<p>In the trial, 106 patients were enrolled from 24 sites. At the start, the randomized treatment and control patients had similar high blood pressures: 178\/97 mmHg and 178\/98 mmHg, respectively, despite both receiving an average daily regimen of five antihypertensive medications. After six months, the average blood pressure of the RDN group was reduced to 146\/85 mmHg, compared to an average blood pressure of 179\/98 mmHg for the control group.<\/p>\n<p>The study also found that the therapy was safe, with no serious device or procedure-related events, no cardiovascular complications, and no kidney-related complications.<\/p>\n<p style=\"text-align: center;\">*\u00a0\u00a0\u00a0\u00a0 *\u00a0\u00a0\u00a0\u00a0 *<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Data from a clinical trial of a hypertension therapy using a catheter indicates the device significantly reduced the treated patients&#8217; blood pressure compared to a control group. Results of the HTN-2 trial of the Symplicity system made by Ardian Inc. of Mountain View, California were reported at the American Heart Association Scientific Sessions 2010 and [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[15],"tags":[31,28,77],"class_list":["post-2099","post","type-post","status-publish","format-standard","hentry","category-products","tag-biomedical","tag-clinical-trials","tag-medical-device"],"_links":{"self":[{"href":"https:\/\/technewslit.com\/sciencebusiness\/index.php?rest_route=\/wp\/v2\/posts\/2099","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/technewslit.com\/sciencebusiness\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/technewslit.com\/sciencebusiness\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/technewslit.com\/sciencebusiness\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/technewslit.com\/sciencebusiness\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2099"}],"version-history":[{"count":5,"href":"https:\/\/technewslit.com\/sciencebusiness\/index.php?rest_route=\/wp\/v2\/posts\/2099\/revisions"}],"predecessor-version":[{"id":3147,"href":"https:\/\/technewslit.com\/sciencebusiness\/index.php?rest_route=\/wp\/v2\/posts\/2099\/revisions\/3147"}],"wp:attachment":[{"href":"https:\/\/technewslit.com\/sciencebusiness\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2099"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/technewslit.com\/sciencebusiness\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2099"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/technewslit.com\/sciencebusiness\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2099"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}